Leslie Nielsen as Lt. Frank Drebin

Priscilla Presley as Jane Spencer

George Kennedy as Ed Hocken

O. J. Simpson as Nordberg

Robert Goulet as Quentin Hapsburg

Richard Griffiths as Dr. Meinheimer / Earl Hacker

Jacqueline Brookes as Commissioner Brumford

Anthony James as Hector Savage

Lloyd Bochner as Baggett

Tim O'Connor as Fenzwick

Peter Mark Richman as Dunwell

Ed Williams as Ted Olsen

John Roarke as George Bush

Margery Jane Ross as Barbara Bush

Peter Van Norden as John Sununu

Gail Neely as Winnie Mandela

Colleen Fitzpatrick as Blues Singer

Sally Rosenblatt as Mrs. Redmond

Alexander Folk as Crackhouse Cop

Jose Gonzales-Gonzales as Mariachi

Larry McCormick as TV Reporter

Cliff Bemis as Barbecue Dad

D.D. Howard as Barbecue Mom

William Woodson as TV Commercial Announcer

Mel Tormé as Mel Tormé

Zsa Zsa Gabor as Zsa Zsa Gabor

Bill Chemerka as "Ladies and Gentlemen, the President of the United States and Mrs. Bush."

Christopher J. Keene as "Hey Ken, Al! Look what I found."

Ken Kerman as "Hey, that's a pretty nice clock."

Al Fann as "It's 4 minutes too slow."

Tom McGreevey as "Vert well, sir. It's from the lady."

James Gilstrap as "Always nice to see nice people."

'Weird Al' Yankovic as "You pigs...say your prayers."

Gina Mastrogiacomo as "Is this some kind of bust?"

Jeff Wright as "Frank, we got that Sure-Grip suck machine..."

C. Lindsay Workman as "Your coat, sir?"

John Stevens as "Phone call, Commissioner"

Gokul as "Hey, what the hell happened to the water pressure?"

Charlotte Zucker as "For a man in a wheelchair, he gets around marvelously."

Don Pugsley as "He's wired!"

Carlos Betancourt as "¡Ojala que se mejoré pronto!"

Bernardo Márquez as "Recuerdos a todos."

Margarito Mendoza as "¿Puede decirme donde esta la casa de musica?"

Lee Terri as "Hey, look what he's doing to that man in the wheelchair!"

Claude Jay McLin as "Yeah!"

Manny Perry as "Let's get him."

Alex Zimmerman as "Yeah!"

Raynor Scheine as "You're on my groin."

John Fleck as "If that's your attitude, forget it."

Susan Breslau as Party Guest

Leslie Maier as Party Guest

Ron Rosenblatt as Mr. Redmond

Jennifer Kretchmer as Barbecue Daughter

Ryan Harrison as Barbecue Boy

David Zucker as Davy Crockett

Robert K. Weiss as Obstetrician

Robert LoCash as FBI Agent

Burton Zucker as Lab Technician

Lewis Friedman as Lab Technician

Bob Reitman as Lab Technician

Gene Mueller as Lab Technician

Gino Salomone as Lab Technician

Robert J. Elisberg as McTigue

Mindy Newborn as Slave to the Composer

Jan Campbell as Lady in Waiting

Wendy Hogan as Lady in Waiting

Françoise Ruggieri as White House Dinner Guest (uncredited)