Natalie Portman as Emma Kurtzman

Ashton Kutcher as Adam Franklin

Kevin Kline as Alvin Franklin

Cary Elwes as Dr. Stephen Metzner

Greta Gerwig as Patrice

Lake Bell as Lucy

Olivia Thirlby as Katie Kurtzman

Ludacris as Wallace

Jake Johnson as Eli

Mindy Kaling as Shira

Talia Balsam as Sandra Kurtzman

Ophelia Lovibond as Vanessa

Guy Branum as Guy

Ben Lawson as Sam

Jennifer Irwin as Megan

Adhir Kalyan as Kevin

Brian H. Dierker as Bones

Abby Elliott as Joy

Vedette Lim as Lisa

Gary David Goldberg as Emma's Relative

Armen Weitzman as Taxi Driver

Shaun Russell as LACMA Guard

Nealla Gordon as Lydia

Seth Morris as Man with Dog

Nasim Pedrad as Writer

Elizabeth Meriwether as Writer

Mollee Gray as Sari

Derek Ferguson as Benji

Matthew Moy as Chuck

Tyne Stecklein as Victoria

Kym Connor as Stage Mom

Renna Bogdanowicz as Stage Assistant Director

Jennifer Hamilton as On Camera Choreographer

Krystal Ellsworth as Secret High Dancer

Kim Marko Germar as Secret High Dancer

Megan Honore as Secret High Dancer

Nick Lanzisera as Secret High Dancer

Moira 'Anjolie' Marfori as Secret High Dancer

Dalphe Morantus as Secret High Dancer

Katrina Norman as Secret High Dancer

Heather Phillips as Secret High Dancer

Britt Stewart as Secret High Dancer

Paula Van Oppen as Secret High Dancer

William Loftis as Secret High Dancer

KC Monnie as Secret High Dancer

Jason Williams as Secret High Dancer

Chulachak Chakrabongse as Bar Group

Jay Barclay as Bar Group

Tom Tangen as Eli's Dad

Tim Matheson as Eli's Dad #2

Ben Lautman as Rabbi

Joshua Andreacola as Boy at Wake

Sam Greenberg as Boy at Wake

Rachel McDermott as STK Waitress

Robert Trapp as Mini-Golfer

Rachael Markarian as Frat Party Dancer

Kherington Payne as Frat Party Dancer

Dylan Doornbos Hayes as Young Adam

Stefanie Scott as Young Emma