Robert Downey Jr. as Peter Highman

Zach Galifianakis as Ethan Tremblay

Michelle Monaghan as Sarah Highman

Jamie Foxx as Darryl

Juliette Lewis as Heidi

Danny McBride as Lonnie

RZA as Airport Screener

Matt Walsh as TSA Agent

Brody Stevens as Limo Driver

Jakob Ulrich as Patrick

Naiia Ulrich as Alex

Todd Phillips as Barry

Bobby Tisdale as Carl

Sharon Conley as Airport X-Ray

Nathalie Fay as Flight Attendant

Emily Wagner as Flight Attendant

Steven M. Gagnon as Air Marshall

Paul Renteria as Border Guard

Marco Rodríguez as Federali Agent

Mimi Kennedy as Sarah's Mom

Tymberlee Hill as New Mother

Keegan-Michael Key as New Father

Aaron Lustig as Dr. Greene

Charlie Sheen as Charlie Harper

Jon Cryer as Alan Harper

Haji Abdullah as Airport Passenger (uncredited)

Jeremy Ambler as TSA Agent (uncredited)

Madeline Brumby as Airport Pedestrian (uncredited)

Joseph Harold as Private Johnson (uncredited)

Sarah Reagin Clemmensen as Airport Security Agent (uncredited)

Connie Sawyer as Elderly Airport Passenger (uncredited)