Oprah Winfrey as Deborah Lacks

Rose Byrne as Rebecca Skloot

Renée Elise Goldsberry as Henrietta Lacks

Reg E. Cathey as Zakariyyah

Courtney B. Vance as Sir Lord Keenan Coefield

Rocky Carroll as Sonny Lacks

Leslie Uggams as Sadie

Reed Birney as Dr. George Gey

John Douglas Thompson as Lawrence Lacks

Adriane Lenox as Barbara Lacks

Roger Robinson as Day Lacks

John Beasley as Cliff

Peter Gerety as Paul Lurz

Gabriel Ebert as Christoph Lengauer

John Benjamin Hickey as Bill Watson

Ruben Santiago-Hudson as Dr. Roland Pattillo

Byron Jennings as Dr. Victor McKusick

Sylvia Grace Crim as Mary Kubicek

Karen Wheeling Reynolds as Mrs. Gey

John C. Vennema as Board Administrator

Jaedon Godley as Davon Lacks

Kyanna Simone Simpson as Deborah (15-24YRS)

Jane Rumbaua as Dr. Susan Hsu

Jaylon Gordon as Alfred

Leon Lamar as Cootie

Andrea Frye as Gladys

Jazzy Ellis as Young Gladys

Tinashe Kajese as Sadie

Patrick Walker as Cousin Fred

L. Warren Young as Day Lacks

Ellen Barkin as Sasha Walz

Michael Gaston as Richard Wilson

Kate Bond as Young Woman

Tyvonna Jones as Elsie Lacks

Bill Martin Williams as Crownsville Administrator

Mary Shaw as Woman at Pump

Tian Richards as Lawrence (16 yrs.)

Kermit Burns III as Young Cootie

Lisa Arrindell as Aunt Ethel

Jordan Eli Arellano as Young Sonny Lacks

Kayla Anderson as Johns Hopkins Student

De'Marco Arrington as Young Joe

Matthew Bernard as Johns Hopkins Student

Raphael Dante' Carr Jr. as Young Sonny

Ninja N. Devoe as Country Girl Mae

Clint Edwards as Scientist

Christopher Robert Escobar as Chris the Intern

Sean Freeland as Charlie

Elizabeth Hackler as Rebecca's Co-worker

Linden Harris as Galen (as Linden Ronel Harris)

Todd Lee as Doctor

Miguel Angel Marrero as Scientist

Sage Mayer as Young Boy

Jock McKissic as Carl the Mechanic

Tatom Pender as Johns Hopkins Nurse

Earl Poitier as Cousin Josh

David Shae as Reporter

Tashaun Stanfill-Perry as Henrietta Lacks Neighbor

Alpha Trivette as First Administrator

Terrence V. Walker as Church Patron