Rose Byrne as Rebecca Skloot

Renée Elise Goldsberry as Henrietta Lacks

Oprah Winfrey as Deborah Lacks

Ninja N. Devoe as Country Girl Mae

Lisa Arrindell as Aunt Ethel

Earl Poitier as Cousin Josh

L. Warren Young as Day Lacks

Patrick Walker as Cousin Fred

Jane Rumbaua as Mrs. Hsu

Sylvia Grace Crim as Mary Kubicek

Tian Richards as Lawrence (16 yrs.)

Kate Bond as Young Woman

Jazzy Ellis as Young Gladys

Jock McKissic as Carl the Mechanic

Kyanna Simone Simpson as Deborah (15-24YRS)

Tinashe Kajese as Sadie

Kayla Anderson as Johns Hopkins Student

Karen Wheeling Reynolds as Mrs. Gey

Todd Lee as Doctor

Jordan Eli Arellano as Young Sonny Lacks

Mary Shaw as Woman at Pump

Tatom Pender as Johns Hopkins Nurse

Christopher Robert Escobar as Chris the Intern

Clint Edwards as Scientist

De'Marco Arrington as Young Joe

Jaylon Gordon as Alfred

Tashaun Stanfill-Perry as Henrietta Lacks Neighbor

Matthew Bernard as Johns Hopkins Student

Sage Mayer as Young Boy

Elizabeth Hackler as Rebecca's Co-worker

David Shae as Reporter

Jaedon Godley as Davon Lacks

Tyvonna Jones as Elsie Lacks

Raphael Dante' Carr Jr. as Young Sonny

Miguel Angel Marrero as Scientist

Courtney B. Vance as Sir Lord Keenan Coefield

Reed Birney as Dr. George Gey

Alpha Trivette as First Administrator

Terrence V. Walker as Church Patron

Sean Freeland as Charlie

Reg E. Cathey as Zakariyyah

Gabriel Ebert as Christoph Lengauer