E. G. Daily as Tommy Pickles (Voice)

Nancy Cartwright as Chuckie Finster (voice)

Kath Soucie as Phil DeVille / Lil DeVille / Betty DeVille (voice)

Cheryl Chase as Angelica Pickles (voice)

Dionne Quan as Kimi Finster (voice)

Tara Strong as Dil Pickles (voice)

Debbie Reynolds as Lulu Pickles (voice)

Jim Belushi as Santa Claus (voice)

Paul Reubens as Hermie the Elf (voice)

Tress MacNeille as Charlotte Pickles (voice)

Julia Kato as Kira Finster (voice)

Melanie Chartoff as Didi Pickles (voice)

Michael Bell as Chas Finster / Drew Pickles (voice)