Seth MacFarlane as Peter Griffin / Stewie Griffin / Stan Smith (voice)

Seth Green as Chris Griffin (voice)

Alex Borstein as Lois Griffin (voice)

Mila Kunis as Meg Griffin (voice)

Mike Henry as Cleveland Brown / Bruce / Jeffry / Consuela (voice)

Patrick Warburton as Joe Swanson (voice)

Patrick Stewart as Avery Bullock (voice)

Simon Cowell as Simon Cowell (voice)

Paula Abdul as Paula Abdul (voice)

Randy Jackson as Randy Jackson (voice)

David Boat as Rupert (voice)

Alexandra Breckenridge as Cancer Sufferer (voice)

Phil LaMarr as Judge (voice)

Adam West as Mayor Adam West (voice)

David Anthony Pizzuto as Willem Dafoe (voice)