Leonardo DiCaprio as Dr. Randall Mindy

Jennifer Lawrence as Kate Dibiasky

Meryl Streep as President Orlean

Cate Blanchett as Brie Evantee

Rob Morgan as Dr. Teddy Oglethorpe

Jonah Hill as Jason Orlean

Mark Rylance as Peter Isherwell

Tyler Perry as Jack Bremmer

Timothée Chalamet as Yule

Ron Perlman as Benedict Drask

Ariana Grande as Riley Bina

Kid Cudi as DJ Chello

Himesh Patel as Phillip

Melanie Lynskey as June Mindy

Michael Chiklis as Dan Pawketty

Tomer Sisley as Adul Grelio

Paul Guilfoyle as General Themes

Robert Joy as Congressman Tenant

Jack Alberts as Oliver

Ting as Win

Lance A. Williams as Daniel

Shimali de Silva as Nisha

Hettienne Park as Dr. Calder

Rafael Silva as Nasa Scientist

Lonnie Farmer as Old Aide #1

Homa Sarabi-Daunis as White House Office Worker

Barbara Douglass as Office Worker

Rena Maliszewski as Anchor Reporting On Colon

Erik Parillo as Sherriff Conlon

Robert Hurst Radochia as Evan Mindy

Conor Sweeney as Marshall Mindy

Ross Partridge as Keith Ollens

Richard Donelly as Old Aide #2

Liev Schreiber as Bash Narrator (voice)

Samsara Yett as Isherwell Child Aide

Meara Mahoney Gross as Isherwell Child Aide

Jaden Onwuakor as Isherwell Child Aide

Staci Roberts as Linda Dicalio

Wendy Bellevue as Isherwell Child Handler

Mishka Yarovoy as Executive

Chris Everett as Chief Editor Paula Woods

Annette Miller as Mrs. Tanken

Stephen Thorne as Benjamin

Aimee Doherty as Passerby

Natalie Rebenkoff as Talent PA

Gary Tanguay as News Anchor #2

Georgia Lyman as Groomer Thalia

Patricia DeHaney as Hair Person

Ben Sidell as Stage Manager

Therese Plaehn as Autopsy Editor In Charge

Omar Ghonim as Damian

Jody O'Neil as Stage Manager #2

Meghan Leathers as Media Quant

Ashleigh Banfield as Dalia Hensfield

Sarah Silverman as Sarah Benterman

Richard Snee as Senator Lerner

Darryl Wooten as FBI Agent

Danielle Waxman as College Girl

Jeffrey Smith as Blind Man FBI Agent

Jon Glaser as Meow Man

Dorothy Dwyer as Old Tough Lady

Odis Spencer as Chief Justice

Sarah Nolen as Sammy Puppeteer

Alvin Keith as Harrison Telms

Alaina Pinto as American Reporter

Lizzie Short as French Reporter

Juri Love as Japanese Reporter

Sujoy De as Hindi Reporter

Brahms Guignard as Haitian Reporter

Sergei Bushmanov as Russian Reporter

Lewis D. Wheeler as Mission Coordinator

Steve Gagliastro as Onlooker

David J. Curtis as Guy

Kevin Craig West as Secretary of State

Alison Weller as Secretary of Education

Rob Lévesque as Secretary of Interior

Sam Zephir as Captain

Dee Nelson as Dr. Lisa Inez

Beau Allen as Dr. Talcamont

Rebecca Gibel as Waitress

Brian Faherty as Guy from the Bar

Celeste Oliva as Nearby Diner

Amanda Cass as Rioting Patron

Roman Mitichyan as Rioting Patron

Paul Marini as Rioting Patron

Alex Huynh as Rioting Patron

Michael Jibrin as Federal Agent

Bill Mootos as Federal Attorney

Patti Tippo as French President

Allyn Burrows as Mr. Dibiasky

Tori Davis Lawlor as Mrs. Dibiasky

Joy Lang as Housewife

June Holmes as Girl in Commercial

Graham Holmes as Boy in Commercial

Jacob Sanditen as Yule's Friend

Anthony Marrese as Other Friend

Caroline Bergwall as Teen Girl Friend

Anania Williams as Short Guy Friend

Nate Richman as Stocky FBI Agent

Wes Johnson as Don't Look Up'er

John Bucy as Don't Look Up'er

Patrick Gover as Don't Look Up'er

Conrad Perry as Don't Look Up'er

Matt Rouillard as Don't Look Up'er

Christopher Deschenes as Don't Look Up'er

Patrick Michael Strange as Just Look Up'er

J.P. Aaron as Just Look Up'er

Daniela August as Just Look Up'er

Nicholai Senat as Puppet Show Kid

Alexandra Zilch as Puppet Show Kid

Jonathan Kobs as Truthslinger303

Bianca de la Garza as Entertainment Journalist

Caitlin Ishibashi as DJ at Concert

Claire Davis as Bass Player

Elder Isaiah Perez as Organ Player

Coran Spardakis Henley as Drummer

Lance Norris as Loyal Supporter

Ralph M. Studley as Kid Rock Body Double

Frank Ridley as Flight Director

Andrew Haserlat as Mission Tech

Jayne McLendon as Command Tech

Ishaan Khatter as Raghav Manavalan

Khaldoun Rajeh as Egyptian Family

Sheren Rajeh as Egyptian Family

Khaled Rajeh as Egyptian Family

Kareem Rajeh as Egyptian Family

Ahmad Rajeh as Egyptian Family

Adila Rajeh as Egyptian Family

J.T. Turner as Old Billionaire

Ed Peed as Lobbyist

Zach Holmes as #LaunchChallenge MeTuber (uncredited)

Chris Evans as Devin Peters (uncredited)

Marissa Carpio as Reporter with Big Hair (uncredited)