Fredric March as William Spence

Martha Scott as Hope Morris Spence

Beulah Bondi as Lydia Sandow

Gene Lockhart as Preston Thurston

Elisabeth Fraser as Eileen Spence at Age 17

Harry Davenport as Elias Samson

Laura Hope Crews as Mrs. Preston Thurston

Grant Mitchell as Clayton Potter

Moroni Olsen as Dr. John Romer

Frankie Thomas as Hartzell Spence

Jerome Cowan as Dr. Horrigan

Ernest Cossart as John E. Morris

Nana Bryant as Mrs. Morris

Carlotta Jelm as Eileen Spence

Peter Caldwell as Hartzell Spence

Casey Johnson as Frazer Spence

Dorothy Adams as Woman Behind Hope at Baptism (uncredited)

Joan Anderson as Child (uncredited)

Roscoe Ates as George Reynolds (uncredited)

Leah Baird as Undetermined Secondary Role (uncredited)

Clara Blandick as Sister Watkins (uncredited)

Hobart Bosworth as Richard Hardy Case (uncredited)

Jed Breslau as Child (uncredited)

Harlan Briggs as Mac MacFarland (uncredited)

Virginia Brissac as Mrs. Jellison (uncredited)

Mary Brodel as Second Bride (uncredited)

Sonny Bupp as Boy (uncredited)

Chester Conklin as Man Crying During Baptism (uncredited)

Ted Crane as Child (uncredited)

Charles Drake as Second Bridegroom (uncredited)

Ann Edmonds as First Bride (uncredited)

Sarah Edwards as Mrs. Spicer (uncredited)

Dick Elliott as Casper Cullenbaugh (uncredited)

Fern Emmett as Woman Gossip (uncredited)

Charles Ferguson as Townsman (uncredited)

Mary Field as Lulu Digby (uncredited)

Inez Gay as Undetermined Secondary Role (uncredited)

Sol Gorss as Panhandler (uncredited)

William Gould as Fire Chief (uncredited)

Creighton Hale as Church Usher (uncredited)

Charles Halton as Haskins (uncredited)

Herbert Heywood as Shopkeeper (uncredited)

Gertrude Hoffmann as Elderly Woman (uncredited)

Olin Howland as Train Station Master (uncredited)

Delos Jewkes as Choir Member (uncredited)

Payne B. Johnson as School Boy (uncredited)

Fred Kelsey as Train Conductor (uncredited)

Milton Kibbee as Alf McAfee (uncredited)

Mickey Kuhn as Boy (uncredited)

Harry Lewis as Young Soldier in Hospital (uncredited)

Vera Lewis as Mrs. Simpson (uncredited)

Audra Lindley as Mother (uncredited)

Becky Mack as Thurstons' Maid (uncredited)

Jean Maddox as First Mother (uncredited)

Hank Mann as Sam (uncredited)

Frank Marlowe as Soldier (uncredited)

Thomas Martin as Fire Watcher (uncredited)

Frank Mayo as Waiting Train Passenger (uncredited)

Robert McKim as Handsome Jack Pressley (archive footage) (uncredited)

Mira McKinney as Movie Theatre Cashier (uncredited)

Freddie Mercer as Choir Member (uncredited)

Bess Meyers as Undetermined Secondary Role (uncredited)

Harold Miller as Second Clerk (uncredited)

Jack Mower as Man Behind Hope at Baptism (uncredited)

George Nichols as Prechin' Bill Hardy (archive footage) (uncredited)

Bob O'Connor as Fire Watcher (uncredited)

Tempe Pigott as Mrs. Dibble (uncredited)

Jane Randolph as Mother (uncredited)

Gus Reed as Choir Member (uncredited)

Frank Reicher as Board Member (uncredited)

Sam Rice as Man Quieting Boys in Theater (uncredited)

Ruth Robinson as Lydia's Maid (uncredited)

Virginia Sale as Sister Sale at the Movie Theatre (uncredited)

Sandy Shaw as Child (uncredited)

Reginald Simpson as Candy Butcher (uncredited)

Walter Soderling as Parishiner Wanting More Sin in Sermon (uncredited)

Charlotte Treadway as Ella Hodges (uncredited)

Paula Trueman as Miss Peabody (uncredited)

Joyce Tucker as Girl (uncredited)

Dorothy Vaughan as Mrs. Ehrlich (uncredited)

Lottie Williams as Undetermined Secondary Role (uncredited)

Tom Wilson as Fireman Angus (uncredited)

Gig Young as First Groom Asking for Dog Licence (uncredited)

Terry Moore as Choir Member (uncredited)