John Goodman as Fred Flintstone

Elizabeth Perkins as Wilma Flintstone

Rick Moranis as Barney Rubble

Rosie O'Donnell as Betty Rubble

Kyle MacLachlan as Cliff Vandercave

Halle Berry as Sharron Stone

Elizabeth Taylor as Pearl Slaghoople

Dann Florek as Mr. Slate

Richard Moll as Hoagie

Irwin Keyes as Joe Rockhead

Jonathan Winters as Gobo The Grizzled Man

Harvey Korman as Ali / Dicabird / Blossom's Adopted Doll Son Ali

Lainey Silver as Pebbles

Melanie Silver as Pebbles

Hlynur Sigurðsson as Bamm-Bamm

Marinó Sigurðsson as Bamm-Bamm

Sheryl Lee Ralph as Mrs. Pyrite

Jean Vander Pyl as Mrs. Feldspar

Janice Kent as Stewardess

Jack O'Halloran as Yeti

Becky Thyre as Roxanne

Rod McCary as Store Manager

Kate Pierson as BC-52's

Fred Schneider as BC-52's

Keith Strickland as BC-52's

Jim Doughan as Maitre d'

Laraine Newman as Susan Rock

Jay Leno as Bedrock's Most Wanted Host

Alan Blumenfeld as Fred Look-A-Like

Messiri Freeman as Miss Stone Look-A-Like

Alex Zimmerman as Accuser

Sam Raimi as Cliff Look-A-Like

Tommy Terrell as Accuser

Andy Steinfeld as Aerobics Instructor

Bradford Bryson as Foreman

Tabbie Brown as Accuser

Dean Cundey as Technician

Lita Stevens as Woman at Chevrox

Joseph Barbera as Man in Mersandes

William Hanna as Executive in Boardroom

Mel Blanc as Dino (voice) (archive sound)

Sam the Orangutan as Mr. Henderson (uncredited)