Matt Damon as Spirit (voice)

James Cromwell as The Colonel (voice)

Charles Napier as Roy (voice)

Robert Cait as Jake (voice)

Richard McGonagle as Bill (voice)

Donald Fullilove as Train Pull Foreman (voice)

Daniel Studi as Little Creek (voice)

Chopper Bernet as Sgt. Adams (voice)

Jeff LeBeau as Murphy / Railroad Foreman (voice)

John Rubano as Soldier (voice)

Matt Levin as Joe (voice)

Adam Paul as Pete (voice)

Meredith Wells as Little Indian Girl (voice)

Zahn McClarnon as Little Creek's Friend (voice)

Michael Horse as Little Creek's Friend (voice)