Matt Damon as Spirit (voice)

James Cromwell as The Colonel (voice)

Daniel Studi as Little Creek (voice)

Chopper Bernet as Sgt. Adams (voice)

Jeff LeBeau as Murphy / Railroad Foreman (voice)

John Rubano as Soldier (voice)

Richard McGonagle as Bill (voice)

Matt Levin as Joe (voice)

Adam Paul as Pete (voice)

Robert Cait as Jake (voice)

Charles Napier as Roy (voice)

Meredith Wells as Little Indian Girl (voice)

Zahn McClarnon as Little Creek's Friend (voice)

Michael Horse as Little Creek's Friend (voice)

Donald Fullilove as Train Pull Foreman (voice)