Breckin Meyer as Jon Arbuckle

Jennifer Love Hewitt as Liz

Billy Connolly as Dargis

Bill Murray as Garfield (voice)

Tim Curry as Prince (voice)

Ian Abercrombie as Smithee

Roger Rees as Mr. Hobbs

Lucy Davis as Abby

Lena Cardwell as Teenage Tourist

Veronica Alicino as Veterinary Assistant

Jane Carr as Mrs. Whitney

Oliver Muirhead as Mr. Greene

JB Blanc as Hotel Porter

Vernee Watson-Johnson as Tourist #2

Russell Milton as Bobby

Ben Falcone as American Tourist

Bryce Lenon as Police Sergeant

Judi Shekoni as Tour Guide

Melanie Tolbert as Waitress

David Kallaway as Darts Guy

Brian Manis as Contractor

Roscoe Lee Browne as Narrator

Greg Ellis as Nigel (voice)

Bob Hoskins as Winston (voice)

Sharon Osbourne as Christophe (voice)

Joe Pasquale as I, Claudius (voice)

Jane Leeves as Eenie (voice)

Jane Horrocks as Meenie (voice)

Richard E. Grant as Preston (voice)

Vinnie Jones as Rommel (voice)

Rhys Ifans as McBunny (voice)

Jim Piddock as Bolero (voice)

Kenneth Danziger as Additional Voice Cast (voice)

Neil Dickson as Additional Voice Cast (voice)

Robin Atkin Downes as Additional Voice Cast (voice)

Johnny Gidcomb as Additional Voice Cast (voice)

Jean Gilpin as Additional Voice Cast (voice)

Andy Kreiss as Additional Voice Cast (voice)

Peter Lavin as Additional Voice Cast (voice)

Susan Leslie as Additional Voice Cast (voice)

Hope Levy as Additional Voice Cast (voice)

Paula J. Newman as Additional Voice Cast (voice)

Justin Shenkarow as Additional Voice Cast (voice)

Mark Sussman as Additional Voice Cast (voice)

Diz White as Additional Voice Cast (voice)

Marie Del Marco as Pub Guest (uncredited)

Ed Pearce as Corgi Footman (uncredited)

Joe Towne as Garfield / Prince / Various Animals (archive sound) (uncredited)

Martin Tyler as Announcer (voice) (uncredited)