Kate Higgins as Frankie Stein (voice)

Salli Saffioti as Cleo de Nile / Clawdeen Wolf (voice)

Debi Derryberry as Draculaura (voice)

Laura Bailey as Lagoona Blue / Nora Bloodgood (voice)

Audu Paden as Ghoulia Yelps / Slow Moe / Manny Taur (voice)

Ogie Banks as Clawd Wolf (voice)

Yuri Lowenthal as Bram Devein / Deuce Gorgon / Gil Webber / Mr. Rotter (voice)

Cam Clarke as Heath Burns / Hoodude Voodude / Van Hellscream / Romulus (voice)

America Young as Toralei Stripe / Howleen Wolf (voice)

Erin Fitzgerald as Abbey Bominable / Spectra Vondergeist (voice)

Wendee Lee as Nefera De Nile / Ms. Crabgrass (voice)

Cindy Robinson as Jackson Jekyll / Holt Hyde / Gory Fangtell (voice)

Gigi Sarroino as Operetta (voice)