Freddie Highmore as Arthur Montgomery

Madonna as Princess Selenia (voice)

Mia Farrow as Daisy Suchot

Jimmy Fallon as Betameche (voice)

David Bowie as Maltazard (voice)

Doug Rand as Arthur's Father

Penny Balfour as Rose Montgomery

Ron Crawford as Archibald Suchot

David Suchet as Narrator (voice)

Jason Bateman as Prince Darkos (voice)

Adam LeFevre as Davido

Robert De Niro as King (voice)

Snoop Dogg as Max (voice)

Jean Bejote Njamba as Chief Matassalai (voice)

Lee Delong as Saleslady

Saul Jephcott as Police Officer #1

Christian Erickson as Antique Dealer

Eric Balliet as Mover #1

Oxmo Puccino as Mover #2

Robert William Bradford as Baliff

Jerry Di Giacomo as Repairman

Bienvenue Kindoki as Matassalai #1

Valéry Koko Kingue as Matassalai #2

Aba Koïta as Matassalai #3

Vincent Mendy as Matassalai #4

Mathar Licka Gueye as Matassalai #5

Tonio Descanvelle as Police Officer #2

Emilio Estevez as Ferryman

Harvey Keitel as Miro

Rob Corddry as Seides

Nate Corddry as Seides

Erik Per Sullivan as Baby Bug / Mino (voice)

Chazz Palminteri as Travel Agent (voice)

Anthony Anderson as Koolomassai (voice)